Fourteen-member macrolides suppress interleukin-8 production but do not promote apoptosis of activated neutrophils.
نویسندگان
چکیده
A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest that 14-member macrolides achieve clinical efficacy for chronic airway diseases partly by suppressing IL-8 production by activated neutrophils, but not by enhancing apoptosis in these cells.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 46 4 شماره
صفحات -
تاریخ انتشار 2002